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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
24.85
Human Site:
S431
Identified Species:
39.05
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
S431
E
N
V
Y
T
P
K
S
A
V
K
N
E
E
Y
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
S431
E
N
V
Y
T
P
K
S
A
V
K
N
E
E
Y
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
S431
E
N
V
Y
T
P
K
S
A
V
K
N
E
E
Y
Dog
Lupus familis
XP_538730
651
74149
S431
E
N
V
Y
M
P
K
S
A
V
K
D
D
D
C
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
S423
E
N
V
C
T
P
K
S
S
V
K
N
E
E
Q
Rat
Rattus norvegicus
P54645
559
63955
T355
A
K
D
F
Y
L
A
T
S
P
P
D
S
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
S435
E
N
L
C
T
P
K
S
A
V
K
N
E
E
Y
Chicken
Gallus gallus
NP_001026680
657
74208
A437
A
N
K
E
N
V
D
A
E
S
A
L
R
N
E
Frog
Xenopus laevis
NP_001081569
651
74289
S431
K
N
E
D
K
E
N
S
N
T
A
V
A
R
D
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
L688
E
N
Q
P
S
S
H
L
T
Y
Q
L
Q
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
E402
K
R
L
R
S
K
E
E
D
D
A
Y
S
P
V
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
G484
T
G
K
N
Y
R
M
G
A
S
T
C
K
S
R
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
P751
V
G
L
P
L
K
T
P
V
R
R
R
S
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
P236
S
G
E
F
N
C
P
P
W
L
S
L
G
A
M
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
S423
T
F
Q
Q
Q
S
K
S
H
Q
K
S
Q
V
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
100
66.6
N.A.
80
0
N.A.
86.6
6.6
13.3
13.3
N.A.
N.A.
0
6.6
0
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
26.6
N.A.
93.3
13.3
20
33.3
N.A.
N.A.
26.6
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
0
0
0
7
7
40
0
20
0
7
7
0
% A
% Cys:
0
0
0
14
0
7
0
0
0
0
0
7
0
0
7
% C
% Asp:
0
0
7
7
0
0
7
0
7
7
0
14
7
7
14
% D
% Glu:
47
0
14
7
0
7
7
7
7
0
0
0
34
34
7
% E
% Phe:
0
7
0
14
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
20
0
0
0
0
0
7
0
0
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
7
0
7
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
14
7
14
0
7
14
47
0
0
0
47
0
7
7
0
% K
% Leu:
0
0
20
0
7
7
0
7
0
7
0
20
0
0
14
% L
% Met:
0
0
0
0
7
0
7
0
0
0
0
0
0
0
7
% M
% Asn:
0
60
0
7
14
0
7
0
7
0
0
34
0
7
0
% N
% Pro:
0
0
0
14
0
40
7
14
0
7
7
0
0
7
0
% P
% Gln:
0
0
14
7
7
0
0
0
0
7
7
0
14
0
7
% Q
% Arg:
0
7
0
7
0
7
0
0
0
7
7
7
7
14
7
% R
% Ser:
7
0
0
0
14
14
0
54
14
14
7
7
20
7
7
% S
% Thr:
14
0
0
0
34
0
7
7
7
7
7
0
0
0
0
% T
% Val:
7
0
34
0
0
7
0
0
7
40
0
7
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
27
14
0
0
0
0
7
0
7
0
0
27
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _